FDSS/µCELL Functional Drug Screening System
is a laboratory screening system that compactly integrates technologies
developed in drug discovery screening, enabling a purpose-built system that is
simple to use.
Simultaneous measurement and analysis of the kinetics of a sample’s
fluorescence or luminescence intensity in all wells at the time of compound
addition are made possible by the high sensitivity two-dimensional sensor
(camera) and dispenser head (96 tip type/384 tip type). Screening various
compounds at high throughput is enabled by measurement under the same
conditions with no time lag between wells.
- GPCR :GPCR
screening can be performed by intracellular Ca2+ assay, cAMP assay and β-arrestin assay.
- Ion channel:Ion channel screening can be performed using intracellular
ion fluorescence indicators.
- Luminescence :Luminescence screening can be performed using
luminescent probes such as luciferase or aequorin.
- BRET/FRET :Screening of protein-protein interaction can be
performed using fluorescence/luminescence energy transfer.
- iPS- cell :Toxicity evaluation and drug discovery screening using iPS cell-derived
cardiomyocytes and neurons can be performed
for fluorescence/luminescence analysis
addition and reading in 96 wells/384 wells
a wide range of measurements with excitation light sources of various
life, high power LED excitation light source
for FRET or BRET by changing wavelength • High speed data capture of 5 ms maximum (optional)
electrical stimulation and reading in 96 wells (optional)
control option available for automation
can be maintained at +35 oC to +37 oC by installing heater
Various data processing and analysis
are possible from the results of measurement
Spatial correction between wells (spatial uniformity)
Negative control correction.Positive control correction
,Baseline subtraction correction (subtract bias) IC/EC graph calculation from
IC/EC graph calculation using Max, Min, Average and