Functional high-throughput drug screening system

FDSS 7000EX

The FDSS7000EX is our high-end model capable of handling 1536-well assays and measuring both fluorescence and luminescence, and is equipped with a variety of functions such as multiple washing.

Many kinds of suspended/adherent cells' real-time kinetic reactions can be measured and analyzed. Various optional parts such as FRET, robot connections, etc. are available. In addition, the FDSS7000EX is expandable for future upgrades.

  • Intracellular calcium ion
  • Membrane potential
  • Ion channel
  • Aequorin
  • FRET
  • Suspended cell

Supports fluorescence assays and luminescence assays with a single sensor

This sensor has a fluorescence detection sensitivity that far exceeds that of conventional fluorescence sensors.
Because the excitation light can be lowered, the cost of purchasing excitation light sources can be reduced.
In addition to high sensitivity, the FDSS7000EX also has a high dynamic range.
The fluorescence changer makes FRET measurements possible

Comparison of calcium mobilities using Aequorin, Fluo-3, and Fura-2 receptor-expressing cells.

The FDSS7000EX supports various types of ion channel assays such as Na+, K+, Cl-, and pH as well as calcium ion assays using fluorescent dyes such as Fura-2, Fluo-3, and Fluo-4.

The FDSS7000EX is utilized in assays where two different fluorescence wavelengths are measured, for example FRET probes(VSP-1, PremoTM), cAMP dyes (FICRhR), simultaneous calcium and membrane potential dyes (multiplexing), and dual reporter gene assays (GFP and DsRed).

Comparison of dose responses provided by  an Aequorin Assay

Cell: CHO  , Substrate: h-CTZ, Ligand: ATP, Measurement time: The ligand is dispensed 10 seconds after

measurement starts. Measured at 1 second intervals for 1 minute and 30 seconds. 

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